منابع مشابه
Kinetic and crystallographic studies of extended-spectrum GES-11, GES-12, and GES-14 β-lactamases.
GES-1 is a class A extended-spectrum β-lactamase conferring resistance to penicillins, narrow- and expanded-spectrum cephalosporins, and ceftazidime. However, GES-1 poorly hydrolyzes aztreonam and cephamycins and exhibits very low k(cat) values for carbapenems. Twenty-two GES variants have been discovered thus far, differing from each other by 1 to 3 amino acid substitutions that affect substra...
متن کاملA Spatial Approach to Speech and Ges- tural Control in Collaborative Virtual En- vironments
This paper explores issues relating to the use of broadcast media such as speech and gesture for interacting with non-human (i.e. application) objects in collaborative virtual environments. These issues arise from a recognition that broadcast media such as these are inherently social in nature and that, in order to join in such media, an object should possess a degree of social awareness. Put i...
متن کاملGES-11, a novel integron-associated GES variant in Acinetobacter baumannii.
New extended-spectrum beta-lactamase GES-11 was detected in Acinetobacter baumannii BM4674. The enzyme conferred resistance to beta-lactams, including aztreonam, and reduced susceptibility to carbapenems. The structural gene was part of a class 1 integron borne by self-transferable plasmid pIP847. GES-type beta-lactamases have not been reported previously in A. baumannii.
متن کاملNomenclature of GES-Type Extended-Spectrum -Lactamases
In two recently published articles, Wachino et al. designated a novel ceftazidime-hydrolyzing class A extended-spectrum -lactamase (ESBL) (GES-a) as GES-3 (4), and a new cephamycin-hydrolyzing and inhibitor-resistant class A ESBL (GESb) as GES-4 (5). In actuality, their articles are fraught with misleading nomenclature of GES-type ESBLs and controvertible conclusions on the relationship between...
متن کاملGES-18, a new carbapenem-hydrolyzing GES-Type β-lactamase from Pseudomonas aeruginosa that contains Ile80 and Ser170 residues.
A clinical isolate of Pseudomonas aeruginosa recovered from the lower respiratory tract of an 81-year-old patient hospitalized in Belgium was sent to the national reference center to determine its resistance mechanism. PCR sequencing identified a new GES variant, GES-18, which differs from the carbapenem-hydrolyzing enzyme GES-5 by a single amino acid substitution (Val80Ile, in the numbering ac...
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ژورنال
عنوان ژورنال: Revista Médica Clínica Las Condes
سال: 2010
ISSN: 0716-8640
DOI: 10.1016/s0716-8640(10)70611-8